Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50592216
Substrate
n/a
Meas. Tech.
ChEMBL_2203370 (CHEMBL5116078)
Ki
116±n/a nM
Citation
 Pilgram, O; Keils, A; Benary, GE; Müller, J; Merkl, S; Ngaha, S; Huber, S; Chevillard, F; Harbig, A; Magdolen, V; Heine, A; Böttcher-Friebertshäuser, E; Steinmetzer, T Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors. Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50592216
Synonyms:
CHEMBL5180406
Type:
Small organic molecule
Emp. Form.:
C33H41N5O6S
Mol. Mass.:
635.774
SMILES:
COc1ccc(c(OC)c1)-c1cccc(c1)S(=O)(=O)N[C@@H](Cc1cccc(c1)C(N)=N)C(=O)N1CCN(CC1)C(=O)C(C)(C)C |r|
Structure:
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