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Target
Serine/threonine-protein kinase N2
Ligand
BDBM27394
Substrate
n/a
Meas. Tech.
ChEMBL_2221491 (CHEMBL5134825)
Ki
130±n/a nM
Citation
 Scott, F; Fala, AM; Takarada, JE; Ficu, MP; Pennicott, LE; Reuillon, TD; Couņago, RM; Massirer, KB; Elkins, JM; Ward, SE Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. Bioorg Med Chem Lett 60:0 (2022) [PubMed] 
Target
Name:
Serine/threonine-protein kinase N2
Synonyms:
PKN2 | PKN2_HUMAN | PRK2 | PRKCL2 | Protein kinase C-like 2 | Protein kinase N2 | Protein-kinase C-related kinase 2 | Serine/threonine-protein kinase N2
Type:
PROTEIN
Mol. Mass.:
112029.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1433151
Residue:
984
Sequence:
MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPRTPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVAASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPGQDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYIADWC
  
Inhibitor
Name:
BDBM27394
Synonyms:
1-methyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one | pyrrolopyridinone scaffold, 16
Type:
Small organic molecule
Emp. Form.:
C13H13N3O
Mol. Mass.:
227.2618
SMILES:
Cn1c2CCNC(=O)c2cc1-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: