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Target
Serine/threonine-protein kinase N1
Ligand
BDBM50596601
Substrate
n/a
Meas. Tech.
ChEMBL_2221494 (CHEMBL5134828)
IC50
520±n/a nM
Citation
 Scott, F; Fala, AM; Takarada, JE; Ficu, MP; Pennicott, LE; Reuillon, TD; Couņago, RM; Massirer, KB; Elkins, JM; Ward, SE Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. Bioorg Med Chem Lett 60:0 (2022) [PubMed] 
Target
Name:
Serine/threonine-protein kinase N1
Synonyms:
PAK1 | PKN | PKN1 | PKN1_HUMAN | PRK1 | PRKCL1 | Protein kinase N1 | Serine/threonine-protein kinase N1/Transforming protein RhoA
Type:
PROTEIN
Mol. Mass.:
103928.39
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1433150
Residue:
942
Sequence:
MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAAASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTPDSRPPFLSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSPGASPGSEARTTGDISVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC
  
Inhibitor
Name:
BDBM50596601
Synonyms:
CHEMBL5175087
Type:
Small organic molecule
Emp. Form.:
C18H15N3O
Mol. Mass.:
289.3312
SMILES:
O=C1NC(Cc2[nH]c(cc12)-c1ccncc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: