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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50172879
Substrate
n/a
Meas. Tech.
ChEMBL_321533 (CHEMBL880593)
IC50
21.5±n/a nM
Citation
 Charton, J; Cazenave Gassiot, A; Girault-Mizzi, S; Debreu-Fontaine, MA; Melnyk, P; Sergheraert, C Synthesis and pharmacological evaluation of Tic-hydantoin derivatives as selective sigma1 ligands. Part 1. Bioorg Med Chem Lett 15:4833-7 (2005) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50172879
Synonyms:
(S)-2-(3-Piperidin-1-yl-propyl)-10,10a-dihydro-5H-imidazo[1,5-b]isoquinoline-1,3-dione | CHEMBL381653
Type:
Small organic molecule
Emp. Form.:
C19H25N3O2
Mol. Mass.:
327.4207
SMILES:
Oc1c2Cc3ccccc3Cn2c(=O)n1CCCN1CCCCC1
Structure:
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