Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50173210
Substrate
n/a
Meas. Tech.
ChEMBL_320973 (CHEMBL885380)
Ki
110±n/a nM
Citation
 Dowling, JE; Vessels, JT; Haque, S; Chang, HX; van Vloten, K; Kumaravel, G; Engber, T; Jin, X; Phadke, D; Wang, J; Ayyub, E; Petter, RC Synthesis of [1,2,4]triazolo[1,5-a]pyrazines as adenosine A2A receptor antagonists. Bioorg Med Chem Lett 15:4809-13 (2005) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_RAT | ADENOSINE A2a | Adenosine A2 receptor | Adenosine A2a receptor (A2a) | Adenosine Receptors A2a (A2a) | Adenosine receptor A2a and A3 | Adenosine receptors A2a | Adora2a | Rat striatal adenosine A2a receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45015.65
Organism:
Rattus norvegicus (rat)
Description:
Rat A2A receptors expressed in CHO cells.
Residue:
410
Sequence:
MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
  
Inhibitor
Name:
BDBM50173210
Synonyms:
2-Furan-2-yl-6-(3-methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamine | CHEMBL372622
Type:
Small organic molecule
Emp. Form.:
C16H13N5O3S
Mol. Mass.:
355.371
SMILES:
CS(=O)(=O)c1cccc(c1)-c1cn2nc(nc2c(N)n1)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: