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Target
Alpha-synuclein
Ligand
BDBM50599472
Substrate
n/a
Meas. Tech.
ChEMBL_2230608 (CHEMBL5144380)
IC50
7800±n/a nM
Citation
 AlNajjar, YT; Gabr, M; ElHady, AK; Salah, M; Wilms, G; Abadi, AH; Becker, W; Abdel-Halim, M; Engel, M Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/?-synuclein aggregation inhibitors with neuroprotective effects. Eur J Med Chem 227:0 (2022) [PubMed] 
Target
Name:
Alpha-synuclein
Synonyms:
NACP | PARK1 | SNCA | SYUA_HUMAN
Type:
Protein
Mol. Mass.:
14451.42
Organism:
Homo sapiens (Human)
Description:
P37840
Residue:
140
Sequence:
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
  
Inhibitor
Name:
BDBM50599472
Synonyms:
CHEMBL5175951
Type:
Small organic molecule
Emp. Form.:
C21H16N4O4S
Mol. Mass.:
420.441
SMILES:
Oc1cccc(c1)C(=O)Nc1ccc(NC(=O)Nc2nc3ccc(O)cc3s2)cc1
Structure:
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