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Target
Succinate-semialdehyde dehydrogenase, mitochondrial
Ligand
BDBM50177405
Substrate
n/a
Meas. Tech.
ChEMBL_332432 (CHEMBL867028)
IC50
15600±n/a nM
Citation
 Tao, YH; Yuan, Z; Tang, XQ; Xu, HB; Yang, XL Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett 16:592-5 (2005) [PubMed]  Article 
Target
Name:
Succinate-semialdehyde dehydrogenase, mitochondrial
Synonyms:
ALDH5A1 | Aldehyde dehydrogenase family 5 member A1 | NAD(+)-dependent succinic semialdehyde dehydrogenase | SSADH | SSDH_HUMAN | Succinate semialdehyde dehydrogenase | Succinate-semialdehyde dehydrogenase, mitochondrial
Type:
PROTEIN
Mol. Mass.:
57224.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459249
Residue:
535
Sequence:
MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
  
Inhibitor
Name:
BDBM50177405
Synonyms:
3-methoxy-4-hydroxybenzaldehyde | 4-hydroxy-3-methoxybenzaldehyde | 4-hydroxy-m-anisaldehyde | CHEMBL13883 | p-hydroxy-m-methoxybenzaldehyde | p-vanillin | vanillin
Type:
Small organic molecule
Emp. Form.:
C8H8O3
Mol. Mass.:
152.1473
SMILES:
COc1cc(C=O)ccc1O
Structure:
Search PDB for entries with ligand similarity: