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Target
Replicative DNA helicase
Ligand
BDBM50178994
Substrate
n/a
Meas. Tech.
ChEMBL_338400 (CHEMBL866546)
IC50
23000±n/a nM
Citation
 McKay, GA; Reddy, R; Arhin, F; Belley, A; Lehoux, D; Moeck, G; Sarmiento, I; Parr, TR; Gros, P; Pelletier, J; Far, AR Triaminotriazine DNA helicase inhibitors with antibacterial activity. Bioorg Med Chem Lett 16:1286-90 (2006) [PubMed]  Article 
Target
Name:
Replicative DNA helicase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
51573.81
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_338400
Residue:
464
Sequence:
MNEITSPEQYDLETTALKVPPHSIEAEQAVLGGLMLDNNAWERVSDSVSDGDFYRHDHRLIFRAIYKLAEANQPIDVVTLSEQLEKEGQLAQVGGLAYLGELAKNIPSVANIKAYAQIIRERATLRQLIGISNEIADSAFHPEGRGANEILDEAERKIFEVAEARPKTGGPVGISDILVKTIDRIDYLFNTTEALTGVSTGFTDLDEKTSGLQPADLIIVAGRPSMGKTTFAMNLVENAVMRTDKAVLVYSLEMPSDSIVMRMLSSLGRIDQTKVRSGKLDDEDWPRLTSAINLLNDKKLFIDDTAGISPSEMRARTRRLVREHGDLALIMIDYLQLMQIPGSSGDNRTNEISEISRSLKALAKEFNCPVIALSQLNRSLEQRPNKRPVNSDLRESGAIEQDADVIMFVYRDEVYHPETEFKGVAEIIIGKQRNGPIGTVRLAFIGKYTRFENLAAGMYNFEDE
  
Inhibitor
Name:
BDBM50178994
Synonyms:
2-(4-(4,6-bis(4-fluorophenylamino)-1,3,5-triazin-2-yl)piperazin-1-yl)ethanol | CHEMBL204910
Type:
Small organic molecule
Emp. Form.:
C21H23F2N7O
Mol. Mass.:
427.4504
SMILES:
OCCN1CCN(CC1)c1nc(Nc2ccc(F)cc2)nc(Nc2ccc(F)cc2)n1
Structure:
Search PDB for entries with ligand similarity: