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Target
Replicative DNA helicase
Ligand
BDBM50178996
Substrate
n/a
Meas. Tech.
ChEMBL_338400 (CHEMBL866546)
IC50
19000±n/a nM
Citation
 McKay, GA; Reddy, R; Arhin, F; Belley, A; Lehoux, D; Moeck, G; Sarmiento, I; Parr, TR; Gros, P; Pelletier, J; Far, AR Triaminotriazine DNA helicase inhibitors with antibacterial activity. Bioorg Med Chem Lett 16:1286-90 (2006) [PubMed]  Article 
Target
Name:
Replicative DNA helicase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
51573.81
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_338400
Residue:
464
Sequence:
MNEITSPEQYDLETTALKVPPHSIEAEQAVLGGLMLDNNAWERVSDSVSDGDFYRHDHRLIFRAIYKLAEANQPIDVVTLSEQLEKEGQLAQVGGLAYLGELAKNIPSVANIKAYAQIIRERATLRQLIGISNEIADSAFHPEGRGANEILDEAERKIFEVAEARPKTGGPVGISDILVKTIDRIDYLFNTTEALTGVSTGFTDLDEKTSGLQPADLIIVAGRPSMGKTTFAMNLVENAVMRTDKAVLVYSLEMPSDSIVMRMLSSLGRIDQTKVRSGKLDDEDWPRLTSAINLLNDKKLFIDDTAGISPSEMRARTRRLVREHGDLALIMIDYLQLMQIPGSSGDNRTNEISEISRSLKALAKEFNCPVIALSQLNRSLEQRPNKRPVNSDLRESGAIEQDADVIMFVYRDEVYHPETEFKGVAEIIIGKQRNGPIGTVRLAFIGKYTRFENLAAGMYNFEDE
  
Inhibitor
Name:
BDBM50178996
Synonyms:
CHEMBL203116 | N2,N4-bis(3,4-difluorophenyl)-N6-(2-morpholinoethyl)-1,3,5-triazine-2,4,6-triamine
Type:
Small organic molecule
Emp. Form.:
C21H21F4N7O
Mol. Mass.:
463.4314
SMILES:
Fc1ccc(Nc2nc(NCCN3CCOCC3)nc(Nc3ccc(F)c(F)c3)n2)cc1F
Structure:
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