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Target
Replicative DNA helicase
Ligand
BDBM50178995
Substrate
n/a
Meas. Tech.
ChEMBL_338400 (CHEMBL866546)
IC50
31000±n/a nM
Citation
 McKay, GA; Reddy, R; Arhin, F; Belley, A; Lehoux, D; Moeck, G; Sarmiento, I; Parr, TR; Gros, P; Pelletier, J; Far, AR Triaminotriazine DNA helicase inhibitors with antibacterial activity. Bioorg Med Chem Lett 16:1286-90 (2006) [PubMed]  Article 
Target
Name:
Replicative DNA helicase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
51573.81
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_338400
Residue:
464
Sequence:
MNEITSPEQYDLETTALKVPPHSIEAEQAVLGGLMLDNNAWERVSDSVSDGDFYRHDHRLIFRAIYKLAEANQPIDVVTLSEQLEKEGQLAQVGGLAYLGELAKNIPSVANIKAYAQIIRERATLRQLIGISNEIADSAFHPEGRGANEILDEAERKIFEVAEARPKTGGPVGISDILVKTIDRIDYLFNTTEALTGVSTGFTDLDEKTSGLQPADLIIVAGRPSMGKTTFAMNLVENAVMRTDKAVLVYSLEMPSDSIVMRMLSSLGRIDQTKVRSGKLDDEDWPRLTSAINLLNDKKLFIDDTAGISPSEMRARTRRLVREHGDLALIMIDYLQLMQIPGSSGDNRTNEISEISRSLKALAKEFNCPVIALSQLNRSLEQRPNKRPVNSDLRESGAIEQDADVIMFVYRDEVYHPETEFKGVAEIIIGKQRNGPIGTVRLAFIGKYTRFENLAAGMYNFEDE
  
Inhibitor
Name:
BDBM50178995
Synonyms:
CHEMBL381819 | N2,N4,N6-tris(3-chlorophenyl)-1,3,5-triazine-2,4,6-triamine
Type:
Small organic molecule
Emp. Form.:
C21H15Cl3N6
Mol. Mass.:
457.743
SMILES:
Clc1cccc(Nc2nc(Nc3cccc(Cl)c3)nc(Nc3cccc(Cl)c3)n2)c1
Structure:
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