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Target
Replicative DNA helicase
Ligand
BDBM50179000
Substrate
n/a
Meas. Tech.
ChEMBL_338400 (CHEMBL866546)
IC50
5000±n/a nM
Citation
 McKay, GA; Reddy, R; Arhin, F; Belley, A; Lehoux, D; Moeck, G; Sarmiento, I; Parr, TR; Gros, P; Pelletier, J; Far, AR Triaminotriazine DNA helicase inhibitors with antibacterial activity. Bioorg Med Chem Lett 16:1286-90 (2006) [PubMed]  Article 
Target
Name:
Replicative DNA helicase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
51573.81
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_338400
Residue:
464
Sequence:
MNEITSPEQYDLETTALKVPPHSIEAEQAVLGGLMLDNNAWERVSDSVSDGDFYRHDHRLIFRAIYKLAEANQPIDVVTLSEQLEKEGQLAQVGGLAYLGELAKNIPSVANIKAYAQIIRERATLRQLIGISNEIADSAFHPEGRGANEILDEAERKIFEVAEARPKTGGPVGISDILVKTIDRIDYLFNTTEALTGVSTGFTDLDEKTSGLQPADLIIVAGRPSMGKTTFAMNLVENAVMRTDKAVLVYSLEMPSDSIVMRMLSSLGRIDQTKVRSGKLDDEDWPRLTSAINLLNDKKLFIDDTAGISPSEMRARTRRLVREHGDLALIMIDYLQLMQIPGSSGDNRTNEISEISRSLKALAKEFNCPVIALSQLNRSLEQRPNKRPVNSDLRESGAIEQDADVIMFVYRDEVYHPETEFKGVAEIIIGKQRNGPIGTVRLAFIGKYTRFENLAAGMYNFEDE
  
Inhibitor
Name:
BDBM50179000
Synonyms:
CHEMBL205726 | N2-(4-chlorophenyl)-N4-(2-morpholinoethyl)-N6-(4-nitrophenyl)-1,3,5-triazine-2,4,6-triamine
Type:
Small organic molecule
Emp. Form.:
C21H23ClN8O3
Mol. Mass.:
470.912
SMILES:
[O-][N+](=O)c1ccc(Nc2nc(NCCN3CCOCC3)nc(Nc3ccc(Cl)cc3)n2)cc1
Structure:
Search PDB for entries with ligand similarity: