Target
Apelin receptor
Ligand
BDBM50600620
Substrate
n/a
Meas. Tech.
ChEMBL_2234642 (CHEMBL5148414)
EC50
31±n/a nM
Citation
 Narayanan, SDai, DVyas Devambatla, RKAlbert, VBruneau-Latour, NVasukuttan, VCiblat, SRehder, KRunyon, SPMaitra, R Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin receptor. Bioorg Med Chem 66:0 (2022) [PubMed] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM50600620
Synonyms:
CHEMBL5169966
Type:
Small organic molecule
Emp. Form.:
C31H39F6N5O2
Mol. Mass.:
627.6641
SMILES:
FC(F)(F)[C@@H]1CCCCN1CC[C@@H](CC(=O)NC1CCC1)NC(=O)c1cc(-c2ccccc2C(F)(F)F)n(n1)C1CCCC1 |r|
Structure:
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