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Target
Apelin receptor
Ligand
BDBM50600623
Substrate
n/a
Meas. Tech.
ChEMBL_2234642 (CHEMBL5148414)
EC50
24±n/a nM
Citation
 Narayanan, S; Dai, D; Vyas Devambatla, RK; Albert, V; Bruneau-Latour, N; Vasukuttan, V; Ciblat, S; Rehder, K; Runyon, SP; Maitra, R Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin receptor. Bioorg Med Chem 66:0 (2022) [PubMed] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM50600623
Synonyms:
CHEMBL5178250
Type:
Small organic molecule
Emp. Form.:
C30H42F3N5O2
Mol. Mass.:
561.682
SMILES:
CC(C)CN(C)CC[C@@H](CC(=O)NC1CCC1)NC(=O)c1cc(-c2ccccc2C(F)(F)F)n(n1)C1CCCC1 |r|
Structure:
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