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Target
Apoptosis regulator Bcl-2
Ligand
BDBM595534
Substrate
n/a
Meas. Tech.
ChEMBL_2236109 (CHEMBL5149881)
IC50
3820±n/a nM
Citation
 Dong, X; Liang, Q; Pan, YZ; Wang, X; Kuo, YC; Chiang, WC; Zhang, X; Williams, NS; Rizo, J; Levine, B; De Brabander, JK Novel Bcl-2 Inhibitors Selectively Disrupt the Autophagy-Specific Bcl-2-Beclin 1 Protein-Protein Interaction. ACS Med Chem Lett 13:1510-1516 (2022) [PubMed] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM595534
Synonyms:
US11591319, ID lqr-9-048
Type:
Small organic molecule
Emp. Form.:
C25H24BrN3O4
Mol. Mass.:
510.38
SMILES:
CC(C)(C)OC(=O)Nc1ccc(cc1)C1=NN(C(C1)c1ccoc1)C(=O)c1ccc(Br)cc1 |t:15|
Structure:
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