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Target
Voltage-dependent L-type calcium channel subunit beta-2
Ligand
BDBM50602415
Substrate
n/a
Meas. Tech.
ChEMBL_2240505 (CHEMBL5154401)
IC50
>30000±n/a nM
Citation
 Lin, S; Du, T; Zhang, J; Wu, D; Tian, H; Zhang, K; Jiang, L; Lu, D; Sheng, L; Li, Y; Ji, M; Chen, X; Xu, H Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site. J Med Chem 65:16372-16391 (2022) [PubMed] 
Target
Name:
Voltage-dependent L-type calcium channel subunit beta-2
Synonyms:
CAB2 | CACB2_HUMAN | CACNB2 | CACNLB2 | Calcium channel voltage-dependent subunit beta 2 | L-type calcium channel alpha-1c/beta-2/alpha2delta-1 | Lambert-Eaton myasthenic syndrome antigen B | MYSB
Type:
PROTEIN
Mol. Mass.:
73595.87
Organism:
Homo sapiens
Description:
ChEMBL_117734
Residue:
660
Sequence:
MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ
  
Inhibitor
Name:
BDBM50602415
Synonyms:
CHEMBL5190568
Type:
Small organic molecule
Emp. Form.:
C22H23N3O3S
Mol. Mass.:
409.501
SMILES:
Cc1ccc(cc1)S(=O)(=O)Nc1cc(ccc1C)C(=O)NCc1ccc(C)nc1
Structure:
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