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Target
Cannabinoid receptor 1
Ligand
BDBM50603266
Substrate
n/a
Meas. Tech.
ChEMBL_2243601 (CHEMBL5157811)
EC50
7.5±n/a nM
Citation
 Papanastasiou, IP; Georgiadis, MO; Iliopoulos-Tsoutsouvas, C; Paronis, CA; Brust, CA; Tran, NK; Ji, L; Ma, X; Wood, JT; Zvonok, N; Tong, F; Bohn, LM; Nikas, SP; Makriyannis, A Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists. Eur J Med Chem 230:0 (2022) [PubMed] 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50603266
Synonyms:
CHEMBL5203712
Type:
Small organic molecule
Emp. Form.:
C25H33NO3
Mol. Mass.:
395.5344
SMILES:
[H][C@@]12CC(=O)CC[C@@]1([H])C(C)(C)Oc1cc(cc(O)c21)C1(CCCCCC#N)CCC1 |r|
Structure:
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