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Target
fMet-Leu-Phe receptor
Ligand
BDBM50604080
Substrate
n/a
Meas. Tech.
ChEMBL_2246783 (CHEMBL5160993)
IC50
43900±n/a nM
Citation
 Mastromarino, M; Favia, M; Schepetkin, IA; Kirpotina, LN; Trojan, E; Niso, M; Carrieri, A; Le?kiewicz, M; Regulska, M; Darida, M; Rossignolo, F; Fontana, S; Quinn, MT; Basta-Kaim, A; Leopoldo, M; Lacivita, E Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders. J Med Chem 65:5004-5028 (2022) [PubMed] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM50604080
Synonyms:
CHEMBL5184396
Type:
Small organic molecule
Emp. Form.:
C21H21FN4O2
Mol. Mass.:
380.4154
SMILES:
Fc1ccc(NC(=O)N[C@H](Cc2ccc(cc2)C#N)C(=O)N2CCCC2)cc1 |r|
Structure:
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