Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM50186586
Substrate
n/a
Meas. Tech.
ChEMBL_352634 (CHEMBL862125)
IC50
300±n/a nM
Citation
 Smart, BP; Oslund, RC; Walsh, LA; Gelb, MH The first potent inhibitor of mammalian group X secreted phospholipase A2: elucidation of sites for enhanced binding. J Med Chem 49:2858-60 (2006) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50186586
Synonyms:
2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2,6-dimethyl-1Hindol-4-yloxy)acetic acid | CHEMBL208429
Type:
Small organic molecule
Emp. Form.:
C21H20N2O5
Mol. Mass.:
380.3939
SMILES:
Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc(C)cc2n1Cc1ccccc1
Structure:
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