Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 2
Ligand
BDBM50186794
Substrate
n/a
Meas. Tech.
ChEMBL_376789 (CHEMBL866614)
Ki
>3000±n/a nM
Citation
 Wu, WL; Burnett, DA; Spring, R; Qiang, L; Sasikumar, TK; Domalski, MS; Greenlee, WJ; O'Neill, K; Hawes, BE Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett 16:3668-73 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 2
Synonyms:
GPR145 | MCHR2 | MCHR2_HUMAN | Melanin Concentrating Hormone 2 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 2 | SLT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38862.16
Organism:
Homo sapiens (Human)
Description:
Melanin Concentrating Hormone 2 GPR145 HUMAN::Q969V1
Residue:
340
Sequence:
MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
  
Inhibitor
Name:
BDBM50186794
Synonyms:
4'-[1-(1-benzyl-piperidin-4-yl)-3-(4-chloro-5-fluoro-1H-benzoimidazol-2-yl)-propyl]-biphenyl-3-carbonitrile | CHEMBL211166
Type:
Small organic molecule
Emp. Form.:
C35H32ClFN4
Mol. Mass.:
563.107
SMILES:
Fc1ccc2nc(CCC(C3CCN(Cc4ccccc4)CC3)c3ccc(cc3)-c3cccc(c3)C#N)[nH]c2c1Cl
Structure:
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