Reaction Details Report a problem with these data
Target
Amiloride-sensitive sodium channel subunit alpha
Ligand
BDBM50190459
Substrate
n/a
Meas. Tech.
ChEMBL_375179 (CHEMBL868533)
IC50
15±n/a nM
Citation
Hirsh, AJ; Molino, BF; Zhang, J; Astakhova, N; Geiss, WB; Sargent, BJ; Swenson, BD; Usyatinsky, A; Wyle, MJ; Boucher, RC; Smith, RT; Zamurs, A; Johnson, MR Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis. J Med Chem 49:4098-115 (2006) [PubMed] Article
More Info.:
Target
Name:
Amiloride-sensitive sodium channel subunit alpha
Synonyms:
Alpha-ENaC | Alpha-NaCH | Amiloride-sensitive sodium channel alpha-subunit | Amiloride-sensitive sodium channel subunit alpha | Epithelial Na(+) channel subunit alpha | Nonvoltage-gated sodium channel 1 subunit alpha | SCNEA | SCNN1 | SCNN1A | SCNNA_HUMAN
Type:
PROTEIN
Mol. Mass.:
75711.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_375179
Residue:
669
Sequence:
MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP