Reaction Details Report a problem with these data
Target
Protein Mdm4
Ligand
BDBM50403528
Substrate
n/a
Meas. Tech.
ChEMBL_2264223
IC50
17±n/a nM
Citation
 Zhang, S; Lou, J; Li, Y; Zhou, F; Yan, Z; Lyu, X; Zhao, Y Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions. J Med Chem 64:10621-10640 (2021) [PubMed] 
Target
Name:
Protein Mdm4
Synonyms:
Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4
Type:
Oncoprotein
Mol. Mass.:
54842.04
Organism:
Homo sapiens (Human)
Description:
The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.
Residue:
490
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
  
Inhibitor
Name:
BDBM50403528
Synonyms:
CHEMBL5280843
Type:
Small organic molecule
Emp. Form.:
C42H38Cl2N6O5
Mol. Mass.:
777.694
SMILES:
C[C@@H](c1cccc(Cl)c1)n1cnc(c1-c1c([nH]c2cc(Cl)ccc12)C(=O)Nc1cc(ccc1N1CCC(CC1)N1CCCOC1=O)C(O)=O)-c1ccccc1 |r,wU:1.0,(-3.34,3.47,;-3.34,5.01,;-4.67,5.78,;-4.67,7.32,;-6.01,8.08,;-7.33,7.32,;-7.33,5.78,;-8.67,5.01,;-6,5.01,;-2,5.78,;-1.67,7.27,;-.13,7.44,;.49,6.07,;-.67,5.01,;-.67,1.92,;.66,1.15,;.32,-.38,;-1.18,-.53,;-2.09,-1.77,;-3.63,-1.6,;-4.4,-2.93,;-4.25,-.19,;-3.34,1.06,;-1.8,.89,;2,1.92,;2,3.46,;3.33,1.15,;4.67,1.92,;4.67,3.47,;6,4.23,;7.33,3.46,;7.33,1.92,;6,1.16,;6,-.38,;7.33,-1.15,;7.33,-2.69,;6,-3.46,;4.67,-2.69,;4.67,-1.15,;6,-5,;4.67,-5.77,;4.67,-7.31,;6,-8.08,;7.33,-7.31,;7.33,-5.77,;8.67,-5,;6,5.77,;7.34,6.54,;4.67,6.54,;1.97,5.67,;3.06,6.76,;4.55,6.36,;4.94,4.88,;3.86,3.79,;2.37,4.18,)|
Structure:
Search PDB for entries with ligand similarity: