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Target
Serine/threonine-protein kinase 25
Ligand
BDBM50243388
Substrate
n/a
Meas. Tech.
ChEMBL_2264838
IC50
460±n/a nM
Citation
 Kiyeleko, S; Hocine, S; Mautino, G; Kuenemann, M; Nawrotek, A; Miallau, L; Vuillard, LM; Mirguet, O; Kotschy, A; Hanessian, S Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25. Bioorg Med Chem Lett 75:0 (2022) [PubMed] 
Target
Name:
Serine/threonine-protein kinase 25
Synonyms:
SOK1 | STK25 | STK25_HUMAN | YSK1
Type:
PROTEIN
Mol. Mass.:
48113.10
Organism:
Human
Description:
ChEMBL_586495
Residue:
426
Sequence:
MAHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLSTLVRPVFGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHNRNHLTSTR
  
Inhibitor
Name:
BDBM50243388
Synonyms:
AT-9283 | US10981896, Compound AT9283
Type:
Small organic molecule
Emp. Form.:
C19H23N7O2
Mol. Mass.:
381.4316
SMILES:
O=C(NC1CC1)Nc1c[nH]nc1-c1nc2cc(CN3CCOCC3)ccc2[nH]1
Structure:
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