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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50193799
Substrate
n/a
Meas. Tech.
ChEMBL_424101 (CHEMBL856747)
IC50
64±n/a nM
Citation
 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Discovery of orally active butyrolactam 11beta-HSD1 inhibitors. Bioorg Med Chem Lett 16:5555-60 (2006) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50193799
Synonyms:
1-(2-adamantyl)-3-benzylpyrrolidin-2-one | CHEMBL218286
Type:
Small organic molecule
Emp. Form.:
C21H27NO
Mol. Mass.:
309.4452
SMILES:
O=C1C(Cc2ccccc2)CCN1[C@H]1C2CC3CC(C2)CC1C3 |wU:13.14,TLB:19:18:22:15.14.13,19:14:17.18.20:22,THB:13:14:17:20.21.22,13:21:17:15.19.14,12:13:17.18.20:22,(8.33,2.74,;8.33,1.12,;9.62,.26,;10.98,.95,;12.27,.12,;12.19,-1.43,;13.48,-2.26,;14.86,-1.54,;14.94,-.02,;13.64,.82,;9.2,-1.2,;7.66,-1.27,;7.13,.17,;5.79,.93,;4.48,.35,;3.49,1.53,;3.37,3.06,;1.95,3.69,;2.89,2.47,;2.95,.93,;4.34,3,;5.8,2.46,;4.81,3.65,)|
Structure:
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