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Target
Integrin alpha-2
Ligand
BDBM50421704
Substrate
n/a
Meas. Tech.
ChEMBL_2269419
IC50
82±n/a nM
Citation
 Kashif Khan, R; Meanwell, NA; Hager, HH Pseudoprolines as stereoelectronically tunable proline isosteres. Bioorg Med Chem Lett 75:0 (2022) [PubMed] 
Target
Name:
Integrin alpha-2
Synonyms:
CD49 antigen-like family member B | CD49B | CD_antigen=CD49b | Collagen receptor | GPIa | ITGA2 | Integrin alpha-2 | Platelet membrane glycoprotein Ia | VLA-2 subunit alpha
Type:
PROTEIN
Mol. Mass.:
129272.19
Organism:
Homo sapiens
Description:
ChEMBL_108124
Residue:
1181
Sequence:
MGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKGNWLLVGSPWSGFPENRMGDVYKCPVDLSTATCEKLNLQTSTSIPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSASFSPATQPCPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYSSQNDILMLGAVGAFGWSGTIVQKTSHGHLIFPKQAFDQILQDRNHSSYLGYSVAAISTGESTHFVAGAPRANYTGQIVLYSVNENGNITVIQAHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMSDLKKEEGRVYLFTIKEGILGQHQFLEGPEGIENTRFGSAIAALSDINMDGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKYSQKILGSDGAFRSHLQYFGRSLDGYGDLNGDSITDVSIGAFGQVVQLWSQSIADVAIEASFTPEKITLVNKNAQIILKLCFSAKFRPTKQNNQVAIVYNITLDADGFSSRVTSRGLFKENNERCLQKNMVVNQAQSCPEHIIYIQEPSDVVNSLDLRVDISLENPGTSPALEAYSETAKVFSIPFHKDCGEDGLCISDLVLDVRQIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTGIVVDFSENLFFASFSLPVDGTEVTCQVAASQKSVACDVGYPALKREQQVTFTINFDFNLQNLQNQASLSFQALSESQEENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSIVHSFEDVGPKFIFSLKVTTGSVPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQTSSSVSFKSENFRHTKELNCRTASCSNVTCWLKDVHMKGEYFVNVTTRIWNGTFASSTFQTVQLTAAAEINTYNPEIYVIEDNTVTIPLMIMKPDEKAEVPTGVIIGSIIAGILLLLALVAILWKLGFFKRKYEKMTKNPDEIDETTELSS
  
Inhibitor
Name:
BDBM50421704
Synonyms:
CHEMBL5276382
Type:
Small organic molecule
Emp. Form.:
C21H24N4O7S
Mol. Mass.:
476.503
SMILES:
OC(=O)[C@H](CNC(=O)NCc1ccccc1)NC(=O)[C@@H]1COCN1S(=O)(=O)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: