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Target
Polyphenol oxidase 2
Ligand
BDBM50608333
Substrate
n/a
Meas. Tech.
ChEMBL_2273505
IC50
>200±n/a nM
Citation
 Yuan, Y; Jin, W; Nazir, Y; Fercher, C; Blaskovich, MAT; Cooper, MA; Barnard, RT; Ziora, ZM Tyrosinase inhibitors as potential antibacterial agents. Eur J Med Chem 187:0 (2020) [PubMed] 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50608333
Synonyms:
CHEMBL5270893
Type:
Small organic molecule
Emp. Form.:
C14H13BF2N4
Mol. Mass.:
286.088
SMILES:
F[B-]1(F)Nc2ccccc2C2=[N+]1NC(C2)c1ccncc1 |c:11|
Structure:
Search PDB for entries with ligand similarity: