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Target
Cell division protein FtsZ
Ligand
BDBM50203126
Substrate
n/a
Meas. Tech.
ChEMBL_2273984
IC50
10000±n/a nM
Citation
 Buroni, S; Makarov, V; Scoffone, VC; Trespidi, G; Riccardi, G; Chiarelli, LR The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens. Eur J Med Chem 190:0 (2020) [PubMed] 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_STAAU | ftsZ
Type:
Protein
Mol. Mass.:
41023.36
Organism:
Staphylococcus aureus
Description:
P0A031
Residue:
390
Sequence:
MLEFEQGFNHLATLKVIGVGGGGNNAVNRMIDHGMNNVEFIAINTDGQALNLSKAESKIQIGEKLTRGLGAGANPEIGKKAAEESREQIEDAIQGADMVFVTSGMGGGTGTGAAPVVAKIAKEMGALTVGVVTRPFSFEGRKRQTQAAAGVEAMKAAVDTLIVIPNDRLLDIVDKSTPMMEAFKEADNVLRQGVQGISDLIAVSGEVNLDFADVKTIMSNQGSALMGIGVSSGENRAVEAAKKAISSPLLETSIVGAQGVLMNITGGESLSLFEAQEAADIVQDAADEDVNMIFGTVINPELQDEIVVTVIATGFDDKPTSHGRKSGSTGFGTSVNTSSNATSKDESFTSNSSNAQATDSVSERTHTTKEDDIPSFIRNREERRSRRTRR
  
Inhibitor
Name:
BDBM50203126
Synonyms:
3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrido[2,1-a]isoquinolin-5-ylium | 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ylium | 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ylium chloride | 9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ylium; chloride | BERBERINE | Berberinechloride | CHEMBL12089 | berberine dimer | cid_12456
Type:
Small organic molecule
Emp. Form.:
C20H18NO4
Mol. Mass.:
336.3607
SMILES:
COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC
Structure:
Search PDB for entries with ligand similarity: