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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50609874
Substrate
n/a
Meas. Tech.
ChEMBL_2279648
Ki
0.640000±n/a nM
Citation
 Köckenberger, J; Fischer, O; Konopa, A; Bergwinkl, S; Mühlich, S; Gmeiner, P; Kutta, RJ; Hübner, H; Keller, M; Heinrich, MR Synthesis, Characterization, and Application of Muscarinergic M J Med Chem 65:16494-16509 (2022) [PubMed] 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Human
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50609874
Synonyms:
CHEMBL5265833
Type:
Small organic molecule
Emp. Form.:
C27H31ClF2N2O2
Mol. Mass.:
488.997
SMILES:
Fc1ccc(NC(=O)OCC2CCN(CCCCCCC#C)CC2)c(c1)-c1ccc(F)c(Cl)c1
Structure:
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