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Target
C-C chemokine receptor type 5
Ligand
BDBM50197763
Substrate
n/a
Meas. Tech.
ChEMBL_453280 (CHEMBL902435)
IC50
750±n/a nM
Citation
 Wei, RG; Arnaiz, DO; Chou, YL; Davey, D; Dunning, L; Lee, W; Lu, SF; Onuffer, J; Ye, B; Phillips, G CCR5 receptor antagonists: discovery and SAR study of guanylhydrazone derivatives. Bioorg Med Chem Lett 17:231-4 (2006) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Homo sapiens (Human)
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
  
Inhibitor
Name:
BDBM50197763
Synonyms:
(E)-1-(2-(4-chlorobenzyloxy)-5-bromobenzylidene)-2-(4,5-dihydro-1H-imidazol-2-yl)hydrazine | CHEMBL394685
Type:
Small organic molecule
Emp. Form.:
C17H16BrClN4O
Mol. Mass.:
407.692
SMILES:
Clc1ccc(-[#6]-[#8]-c2ccc(Br)cc2-[#6]=[#7]\[#7]=[#6]-2\[#7]-[#6]-[#6]-[#7]-2)cc1 |w:14.14|
Structure:
Search PDB for entries with ligand similarity: