Reaction Details Report a problem with these data
Target
Monocarboxylate transporter 4
Ligand
BDBM50610868
Substrate
n/a
Meas. Tech.
ChEMBL_2282172
Ki
301±n/a nM
Citation
Heinrich, T; Sala-Hojman, A; Ferretti, R; Petersson, C; Minguzzi, S; Gondela, A; Ramaswamy, S; Bartosik, A; Czauderna, F; Crowley, L; Wahra, P; Schilke, H; Böpple, P; Dudek, ?; Le?, M; Niedziejko, P; Olech, K; Pawlik, H; W?oszczak, ?; Zuchowicz, K; Suarez Alvarez, JR; Martyka, J; Sitek, E; Mikulski, M; Szcz??niak, J; Jäckel, S; Krier, M; Król, M; Wegener, A; Ga??zowski, M; Nowak, M; Becker, F; Herhaus, C Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology. J Med Chem 64:11904-11933 (2021) [PubMed]
More Info.:
Target
Name:
Monocarboxylate transporter 4
Synonyms:
MCT 4 | Mct4 | Monocarboxylate transporter 4 | Slc16a3 | Solute carrier family 16 member 3
Type:
PROTEIN
Mol. Mass.:
50378.35
Organism:
Mus musculus
Description:
ChEMBL_120313
Residue:
470
Sequence:
MGGAVVDEGPTGIKAPDGGWGWAVLFGCFIITGFSYAFPKAVSVFFKELMHEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQIYLTTGVITGLGLALNFQPSLIMLNRYFNKRRPIANGLAAAGSPVFLCALSPLGQLLQDHYGWRGGFLILGGLLLNCCVCAALMRPLVAPQVGGGTEPRGPQRPPQRLLDLSVFRDRGFLIYAVAASIMVLGLFVPPVFVVSYAKDMGVPDTKAAFLLTILGFIDIFARPTAGFITGLKKVRPYSVYLFSFAMFFNGFTDLTGSTATDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLLEAVAVLIGPPSGGKLLDATKVYKYVFILAGAEVLTSSLVLLLGNFFCIGKRKRPEVTEPEEVASEEKLHKPPVDVGVDSREVEHFLKAEPEKNGEVVHTPETSV
Inhibitor
Name:
BDBM50610868
Synonyms:
CHEMBL5282978
Type:
Small organic molecule
Emp. Form.:
C67H76N6O21S5
Mol. Mass.:
1461.673
SMILES:
CC1(C)\C(=C\C=C\C=C\C2=[N+](CCCS([O-])(=O)=O)c3ccc(cc3C2(C)CCCCCC(=O)NCCOCCOCCOCCOc2ccnc3c(cccc23)S(=O)(=O)Nc2ccccc2C#Cc2ccc(nc2)C(O)=O)S(O)(=O)=O)N(CCCS(O)(=O)=O)c2ccc(cc12)S(O)(=O)=O |c:9|