Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50197997
Substrate
n/a
Meas. Tech.
ChEMBL_453298 (CHEMBL902453)
IC50
6475±n/a nM
Citation
Pinkerton, AB; Huang, D; Cube, RV; Hutchinson, JH; Struthers, M; Ayala, JM; Vicario, PP; Patel, SR; Wisniewski, T; DeMartino, JA; Vernier, JM Diaryl substituted pyrazoles as potent CCR2 receptor antagonists. Bioorg Med Chem Lett 17:807-13 (2007) [PubMed] Article
More Info.:
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
Inhibitor
Name:
BDBM50197997
Synonyms:
4-(1-(3,5-bis(trifluoromethyl)phenyl)-3-(3,5-dichlorophenyl)-1H-pyrazol-5-yl)-N-(5-(diethylamino)pentan-2-yl)butanamide | CHEMBL239145
Type:
Small organic molecule
Emp. Form.:
C30H34Cl2F6N4O
Mol. Mass.:
651.514
SMILES:
CCN(CC)CCCC(C)NC(=O)CCCc1cc(nn1-c1cc(cc(c1)C(F)(F)F)C(F)(F)F)-c1cc(Cl)cc(Cl)c1 |w:8.8|