Reaction Details Report a problem with these data
Target
Sterol O-acyltransferase 2
Ligand
BDBM50611394
Substrate
n/a
Meas. Tech.
ChEMBL_2283460
IC50
240±n/a nM
Citation
 Bhattacharjee, P; Rutland, N; Iyer, MR Targeting Sterol  J Med Chem 65:16062-16098 (2022) [PubMed] 
Target
Name:
Sterol O-acyltransferase 2
Synonyms:
ACACT2 | ACAT-2 | ACAT2 | Acetyl-CoA acetyltransferase, cytosolic | Acetyl-CoA transferase-like protein | Acyl coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | Cytosolic acetoacetyl-CoA thiolase | SOAT2 | SOAT2_HUMAN
Type:
Enzyme
Mol. Mass.:
59912.75
Organism:
Homo sapiens (Human)
Description:
O75908
Residue:
522
Sequence:
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
  
Inhibitor
Name:
BDBM50611394
Synonyms:
CHEMBL5283833
Type:
Small organic molecule
Emp. Form.:
C37H51NO8
Mol. Mass.:
637.8027
SMILES:
[H][C@]12[#8][C@@]11[C@]([H])([#6]-[#6][C@]3([#6])[C@]4([#6])[C@]([H])([#6][C@@]5([#8])c6c(-[#7][C@@]45[#8])cccc6-[#6]-[#6]4-[#8]C4([#6])[#6])[#6]-[#6][C@@]13[#8])[#8][C@@]1([H])[C@@]2([H])[#8]-[#6@@H](-[#8]C1([#6])[#6])\[#6]=[#6](\[#6])-[#6] |r|
Structure:
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