Reaction Details Report a problem with these data
Target
Sterol O-acyltransferase 2
Ligand
BDBM50611400
Substrate
n/a
Meas. Tech.
ChEMBL_2283460
IC50
1272±n/a nM
Citation
 Bhattacharjee, P; Rutland, N; Iyer, MR Targeting Sterol  J Med Chem 65:16062-16098 (2022) [PubMed] 
Target
Name:
Sterol O-acyltransferase 2
Synonyms:
ACACT2 | ACAT-2 | ACAT2 | Acetyl-CoA acetyltransferase, cytosolic | Acetyl-CoA transferase-like protein | Acyl coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | Cytosolic acetoacetyl-CoA thiolase | SOAT2 | SOAT2_HUMAN
Type:
Enzyme
Mol. Mass.:
59912.75
Organism:
Homo sapiens (Human)
Description:
O75908
Residue:
522
Sequence:
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
  
Inhibitor
Name:
BDBM50611400
Synonyms:
CHEMBL5279156
Type:
Small organic molecule
Emp. Form.:
C27H31NO10
Mol. Mass.:
529.5357
SMILES:
[H][C@]1(C[C@H](OC(C)=O)[C@@]2(C)Oc3cc(oc(=O)c3[C@@H](O)[C@]2([H])C1)-c1cccnc1)[C@](C)(COC(C)=O)OC(C)=O |r|
Structure:
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