Reaction Details Report a problem with these data
Target
Sterol O-acyltransferase 2
Ligand
BDBM50611415
Substrate
n/a
Meas. Tech.
ChEMBL_2283464
IC50
860±n/a nM
Citation
 Bhattacharjee, P; Rutland, N; Iyer, MR Targeting Sterol  J Med Chem 65:16062-16098 (2022) [PubMed] 
Target
Name:
Sterol O-acyltransferase 2
Synonyms:
ACACT2 | ACAT-2 | ACAT2 | Acetyl-CoA acetyltransferase, cytosolic | Acetyl-CoA transferase-like protein | Acyl coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | Cytosolic acetoacetyl-CoA thiolase | SOAT2 | SOAT2_HUMAN
Type:
Enzyme
Mol. Mass.:
59912.75
Organism:
Homo sapiens (Human)
Description:
O75908
Residue:
522
Sequence:
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
  
Inhibitor
Name:
BDBM50611415
Synonyms:
CHEMBL5265938
Type:
Small organic molecule
Emp. Form.:
C35H36N2O10
Mol. Mass.:
644.6677
SMILES:
[H][C@]12[C@@H](O)c3c(O[C@]1(C)[C@H](C[C@@H](C(COC(C)=O)COC(C)=O)C2(C)C)OC(=O)c1ccc(cc1)C#N)cc(oc3=O)-c1cccnc1 |r|
Structure:
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