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Target
C-X-C chemokine receptor type 3
Ligand
BDBM50198407
Substrate
n/a
Meas. Tech.
ChEMBL_437683 (CHEMBL905958)
Ki
108±n/a nM
Citation
 Allen, DR; Bolt, A; Chapman, GA; Knight, RL; Meissner, JW; Owen, DA; Watson, RJ Identification and structure-activity relationships of 1-aryl-3-piperidin-4-yl-urea derivatives as CXCR3 receptor antagonists. Bioorg Med Chem Lett 17:697-701 (2007) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 3
Synonyms:
AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40665.65
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
368
Sequence:
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
  
Inhibitor
Name:
BDBM50198407
Synonyms:
1-(1-(cyclooctenylmethyl)piperidin-4-yl)-3-(5-phenylthiophen-2-yl)urea | CHEMBL242268
Type:
Small organic molecule
Emp. Form.:
C25H33N3OS
Mol. Mass.:
423.614
SMILES:
O=C(NC1CCN(C\C2=C\CCCCCC2)CC1)Nc1ccc(s1)-c1ccccc1 |t:8|
Structure:
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