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Target
Histone deacetylase 1
Ligand
BDBM50612556
Substrate
n/a
Meas. Tech.
ChEMBL_2288779
IC50
458±n/a nM
Citation
 Hamdi, A; Elhusseiny, WM; Othman, DIA; Haikal, A; Bakheit, AH; El-Azab, AS; Al-Agamy, MHM; Abdel-Aziz, AA Synthesis, antitumor, and apoptosis-inducing activities of novel 5-arylidenethiazolidine-2,4-dione derivatives: Histone deacetylases inhibitory activity and molecular docking study. Eur J Med Chem 244:0 (2022) [PubMed] 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50612556
Synonyms:
CHEMBL5291493
Type:
Small organic molecule
Emp. Form.:
C23H19BrN4O4S
Mol. Mass.:
527.39
SMILES:
Cc1c(NC(=O)CN2C(=O)S\C(=C/c3ccc(Br)cc3)C2=O)c(=O)n(-c2ccccc2)n1C
Structure:
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