Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50613230
Substrate
n/a
Meas. Tech.
ChEMBL_2291522
Ki
>5000±n/a nM
Citation
 Abatematteo, FS; Majellaro, M; Montsch, B; Prieto-Díaz, R; Niso, M; Contino, M; Stefanachi, A; Riganti, C; Mangiatordi, GF; Delre, P; Heffeter, P; Sotelo, E; Abate, C Development of Fluorescent 4-[4-(3 J Med Chem 66:3798-3817 (2023) [PubMed] 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50613230
Synonyms:
CHEMBL5284210
Type:
Small organic molecule
Emp. Form.:
C39H48N4O6
Mol. Mass.:
668.8216
SMILES:
COc1cc2CCN(CCCN3CCc4c(OCCCCCCN5C(=O)c6ccc(cc6C5=O)N(C)C)cccc4C3=O)Cc2cc1OC
Structure:
Search PDB for entries with ligand similarity: