Reaction Details Report a problem with these data
Target
tRNA (cytosine(38)-C(5))-methyltransferase
Ligand
BDBM50613354
Substrate
n/a
Meas. Tech.
ChEMBL_2292005
Kd
4200±n/a nM
Citation
 Schwickert, M; Zimmermann, RA; Habeck, T; Hoba, SN; Nidoieva, Z; Fischer, TR; Stark, MM; Kersten, C; Lermyte, F; Helm, M; Schirmeister, T Covalent  ACS Med Chem Lett 14:777-787 (2023) [PubMed] 
Target
Name:
tRNA (cytosine(38)-C(5))-methyltransferase
Synonyms:
2.1.1.204 | DNA (cytosine-5)-methyltransferase-like protein 2 | DNA MTase homolog HsaIIP | DNA methyltransferase homolog HsaIIP | DNMT2 | M.HsaIIP | PuMet | TRDMT1 | TRDMT_HUMAN
Type:
PROTEIN
Mol. Mass.:
44593.53
Organism:
Homo sapiens
Description:
ChEMBL_118874
Residue:
391
Sequence:
MEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE
  
Inhibitor
Name:
BDBM50613354
Synonyms:
CHEMBL5278294
Type:
Small organic molecule
Emp. Form.:
C22H25F3N8O7
Mol. Mass.:
570.4785
SMILES:
N[C@@H](CCN(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)Cc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O)C(O)=O |r|
Structure:
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