Reaction Details Report a problem with these data
Target
O-acetylserine sulfhydrylase
Ligand
BDBM50615378
Substrate
n/a
Meas. Tech.
ChEMBL_2302133
IC50
29400±n/a nM
Citation
 Brunner, K; Steiner, EM; Reshma, RS; Sriram, D; Schnell, R; Schneider, G Profiling of in vitro activities of urea-based inhibitors against cysteine synthases from Mycobacterium tuberculosis. Bioorg Med Chem Lett 27:4582-4587 (2017) [PubMed] 
Target
Name:
O-acetylserine sulfhydrylase
Synonyms:
CSase A | CYSK_MYCTU | Cysteine synthase A | MT2397 | O-acetylserine (thiol)-lyase A | O-acetylserine-specific cysteine synthase | OAS sulfhydrylase | OAS-TL A | OASS | Sulfide-dependent cysteine synthase | cysK | cysK1
Type:
PROTEIN
Mol. Mass.:
32747.29
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_978239
Residue:
310
Sequence:
MSIAEDITQLIGRTPLVRLRRVTDGAVADIVAKLEFFNPANSVKDRIGVAMLQAAEQAGLIKPDTIILEPTSGNTGIALAMVCAARGYRCVLTMPETMSLERRMLLRAYGAELILTPGADGMSGAIAKAEELAKTDQRYFVPQQFENPANPAIHRVTTAEEVWRDTDGKVDIVVAGVGTGGTITGVAQVIKERKPSARFVAVEPAASPVLSGGQKGPHPIQGIGAGFVPPVLDQDLVDEIITVGNEDALNVARRLAREEGLLVGISSGAATVAALQVARRPENAGKLIVVVLPDFGERYLSTPLFADVAD
  
Inhibitor
Name:
BDBM50615378
Synonyms:
CHEMBL5269281
Type:
Small organic molecule
Emp. Form.:
C14H11BrN2O4
Mol. Mass.:
351.152
SMILES:
OC(=O)c1ccc(NC(=O)Nc2ccc(Br)cc2)cc1O
Structure:
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