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Target
Histamine H3 receptor
Ligand
BDBM50615416
Substrate
n/a
Meas. Tech.
ChEMBL_2302322
Ki
17±n/a nM
Citation
 Ledneczki, I; Tapolcsányi, P; Gábor, E; Éles, J; Greiner, I; Schmidt, É; Némethy, Z; Kedves, RS; Balázs, O; Román, V; Lévay, G; Mahó, S Discovery of novel steroidal histamine H Bioorg Med Chem Lett 27:4525-4530 (2017) [PubMed] 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50615416
Synonyms:
CHEMBL5286329
Type:
Small organic molecule
Emp. Form.:
C29H44N2O2
Mol. Mass.:
452.6719
SMILES:
[H][C@@]12CC[C@H](N3CCCC3)[C@@]1(C)CC[C@]1([H])c3ccc(OCCCN4CCC(O)C4)cc3CC[C@@]21[H] |r|
Structure:
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