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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50095261
Substrate
n/a
Meas. Tech.
ChEMBL_2302587
IC50
1600±n/a nM
Citation
 Kaur, R; Dahiya, L; Kumar, M Fructose-1,6-bisphosphatase inhibitors: A new valid approach for management of type 2 diabetes mellitus. Eur J Med Chem 141:473-505 (2017) [PubMed] 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50095261
Synonyms:
(3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine | 4-(3'-chloroanilino)-6,7-diethoxyquinazoline hydrochloride | CHEMBL64950
Type:
Small organic molecule
Emp. Form.:
C18H18ClN3O2
Mol. Mass.:
343.807
SMILES:
CCOc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OCC
Structure:
Search PDB for entries with ligand similarity: