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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50208563
Substrate
n/a
Meas. Tech.
ChEMBL_429368 (CHEMBL916758)
Kd
458±n/a nM
Citation
 Kang, SU; Choi, WJ; Oishi, S; Lee, K; Karki, RG; Worthy, KM; Bindu, LK; Nicklaus, MC; Fisher, RJ; Burke, TR Examination of acylated 4-aminopiperidine-4-carboxylic acid residues in the phosphotyrosyl+1 position of Grb2 SH2 domain-binding tripeptides. J Med Chem 50:1978-82 (2007) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50208563
Synonyms:
(R)-4-(4-(((S)-4-amino-1-(3-(naphthalen-2-yl)propylamino)-1,4-dioxobutan-2-yl)carbamoyl)-1-(3-(5-methyl-1H-indol-1-yl)propanoyl)piperidin-4-ylamino)-3-(4-(phosphonomethyl)benzyl)-4-oxobutanoic acid | CHEMBL376024
Type:
Small organic molecule
Emp. Form.:
C47H55N6O10P
Mol. Mass.:
894.9476
SMILES:
Cc1ccc2n(CCC(=O)N3CCC(CC3)(NC(=O)[C@@H](CC(O)=O)Cc3ccc(CP(O)(O)=O)cc3)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCc3ccc4ccccc4c3)ccc2c1
Structure:
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