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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50213665
Substrate
n/a
Meas. Tech.
ChEMBL_447480 (CHEMBL896503)
IC50
0.6±n/a nM
Citation
Chen, M; Guo, Z; Lanier, MC; Zhao, L; Betz, SF; Huang, CQ; Loweth, CJ; Ashweek, NJ; Liu, XJ; Struthers, RS; Bradbury, MJ; Behan, JW; Wen, J; O'Brien, Z; Saunders, J; Zhu, YF Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists. Bioorg Med Chem Lett 17:3845-50 (2007) [PubMed] Article
More Info.:
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rat
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
Inhibitor
Name:
BDBM50213665
Synonyms:
(S)-1-(3-(1-(4-(1H-tetrazol-5-yl)phenethylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone | CHEMBL413245
Type:
Small organic molecule
Emp. Form.:
C36H37F4N7O
Mol. Mass.:
659.7189
SMILES:
C[C@H](CNCCc1ccc(cc1)-c1nnn[nH]1)c1c2CN(CCc2[nH]c1-c1cc(C)cc(C)c1)C(=O)Cc1c(F)cccc1C(F)(F)F |r|