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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50222998
Substrate
n/a
Meas. Tech.
ChEMBL_458068 (CHEMBL925405)
Ki
337±n/a nM
Citation
 Corbett, JW; Rauckhorst, MR; Qian, F; Hoffman, RL; Knauer, CS; Fitzgerald, LW Heteroatom-linked indanylpyrazines are corticotropin releasing factor type-1 receptor antagonists. Bioorg Med Chem Lett 17:6250-6 (2007) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50222998
Synonyms:
3,6-diethyl-N-(2-isopropoxy-1-phenylethyl)-5-(4-methylpyridin-2-yloxy)pyrazin-2-amine | CHEMBL249430
Type:
Small organic molecule
Emp. Form.:
C25H32N4O2
Mol. Mass.:
420.5472
SMILES:
CCc1nc(Oc2cc(C)ccn2)c(CC)nc1NC(COC(C)C)c1ccccc1 |w:19.20|
Structure:
Search PDB for entries with ligand similarity: