Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50223013
Substrate
n/a
Meas. Tech.
ChEMBL_458068 (CHEMBL925405)
Ki
1207±n/a nM
Citation
 Corbett, JW; Rauckhorst, MR; Qian, F; Hoffman, RL; Knauer, CS; Fitzgerald, LW Heteroatom-linked indanylpyrazines are corticotropin releasing factor type-1 receptor antagonists. Bioorg Med Chem Lett 17:6250-6 (2007) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Human
Description:
P34998
Residue:
415
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50223013
Synonyms:
CHEMBL400155 | N-(cyclopropylmethyl)-3,6-dimethyl-5-(4-methylpyridin-2-yloxy)-N-propylpyrazin-2-amine
Type:
Small organic molecule
Emp. Form.:
C19H26N4O
Mol. Mass.:
326.4359
SMILES:
CCCN(CC1CC1)c1nc(C)c(Oc2cc(C)ccn2)nc1C
Structure:
Search PDB for entries with ligand similarity: