Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50227754
Substrate
n/a
Meas. Tech.
ChEMBL_452357 (CHEMBL902596)
IC50
9336±n/a nM
Citation
 Shi, QCanada, EJXu, YWarshawsky, AMEtgen, GJBroderick, CLClutinger, CKIrwin, LALaurila, MEMontrose-Rafizadeh, COldham, BAWang, MWinneroski, LLXie, CYork, JSYumibe, NPZink, RWMantlo, N Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists. Bioorg Med Chem Lett 17:6744-9 (2008) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50227754
Synonyms:
(R)-3-(4-(3-(1-(5-chloro-3-methylbenzo[b]thiophene-2-carboxamido)ethyl)-5-fluorophenoxy)-2-ethylphenyl)propanoic acid | CHEMBL401236
Type:
Small organic molecule
Emp. Form.:
C29H27ClFNO4S
Mol. Mass.:
540.045
SMILES:
CCc1cc(Oc2cc(F)cc(c2)[C@@H](C)NC(=O)c2sc3ccc(Cl)cc3c2C)ccc1CCC(O)=O
Structure:
Search PDB for entries with ligand similarity: