Reaction Details Report a problem with these data
Target
P2X purinoceptor 7
Ligand
BDBM50251605
Substrate
n/a
Meas. Tech.
ChEMBL_488542 (CHEMBL982857)
IC50
110±n/a nM
Citation
 Betschmann, P; Bettencourt, B; Donnelly-Roberts, D; Friedman, M; George, J; Hirst, G; Josephsohn, N; Konopacki, D; Li, B; Maull, J; Morytko, MJ; Moore, NS; Namovic, M; Rafferty, P; Salmeron-Garcia, JA; Tarcsa, E; Wang, L; Woller, K Synthesis and activity of N-cyanoguanidine-piperazine P2X7 antagonists. Bioorg Med Chem Lett 18:3848-51 (2008) [PubMed]  Article 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7_RAT | P2X purinoceptor 7 | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2X7 rat | P2Z receptor | P2rx7 | Purinergic receptor
Type:
Protein
Mol. Mass.:
68403.50
Organism:
Rattus norvegicus (Rat)
Description:
Q64663
Residue:
595
Sequence:
MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISSVHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCPEYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPALLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGENFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYKENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYASTCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKSLQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCGNCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEAINSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
  
Inhibitor
Name:
BDBM50251605
Synonyms:
4-(carbamimidoyl)-N-(4-chlorophenyl)-2-isopropylpiperazine-1-carboxamide | CHEMBL516911
Type:
Small organic molecule
Emp. Form.:
C23H27ClN6O
Mol. Mass.:
438.953
SMILES:
CC(C)C1CN(CCN1C(=O)Nc1ccc(Cl)cc1)C(NC#N)=Nc1ccccc1C |w:23.25|
Structure:
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