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Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50102008
Substrate
n/a
Meas. Tech.
ChEMBL_509626 (CHEMBL1001387)
Ki
96.7±n/a nM
Citation
 Funke, U; Fischer, S; Hiller, A; Scheunemann, M; Deuther-Conrad, W; Brust, P; Steinbach, J 3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinoline-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: chemical synthesis, evaluation in vitro and radiofluorination. Bioorg Med Chem Lett 18:4727-30 (2008) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Homo sapiens (Human)
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM50102008
Synonyms:
3-[4-(6-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-cyclohexyl]-1H-indole-5-carbonitrile | CHEMBL293583 | trans-3-(4-(6-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C25H27N3O
Mol. Mass.:
385.5014
SMILES:
COc1ccc2CN(CCc2c1)[C@H]1CC[C@@H](CC1)c1c[nH]c2ccc(cc12)C#N |r,wU:15.20,wD:12.13,(32.14,4.98,;30.81,5.75,;29.47,4.98,;29.47,3.44,;28.13,2.68,;26.81,3.46,;25.49,2.69,;24.15,3.46,;24.15,5,;25.49,5.76,;26.82,4.99,;28.15,5.75,;22.82,2.69,;21.48,3.46,;20.15,2.69,;20.15,1.16,;21.49,.38,;22.82,1.15,;18.82,.38,;18.67,-1.16,;17.15,-1.49,;16.37,-.15,;14.86,.16,;14.38,1.63,;15.41,2.78,;16.92,2.47,;17.4,1.01,;14.93,4.24,;14.45,5.7,)|
Structure:
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