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Target
C-C chemokine receptor type 4
Ligand
BDBM50245114
Substrate
n/a
Meas. Tech.
ChEMBL_512155 (CHEMBL980949)
IC50
130±n/a nM
Citation
 Yokoyama, K; Ishikawa, N; Igarashi, S; Kawano, N; Masuda, N; Hattori, K; Miyazaki, T; Ogino, S; Orita, M; Matsumoto, Y; Takeuchi, M; Ohta, M Potent CCR4 antagonists: synthesis, evaluation, and docking study of 2,4-diaminoquinazolines. Bioorg Med Chem 16:7968-74 (2008) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 4
Synonyms:
C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5
Type:
Enzyme
Mol. Mass.:
41406.41
Organism:
Homo sapiens (Human)
Description:
P51679
Residue:
360
Sequence:
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
  
Inhibitor
Name:
BDBM50245114
Synonyms:
CHEMBL488855 | N-(4-Chlorophenyl)-6,7-dimethoxy-2-[4-(2-piperidin-1-ylethyl)-1,4-diazepan-1-yl]quinazolin-4-amine
Type:
Small organic molecule
Emp. Form.:
C28H37ClN6O2
Mol. Mass.:
525.085
SMILES:
COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCCN(CCN2CCCCC2)CC1
Structure:
Search PDB for entries with ligand similarity: