Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 2
Ligand
BDBM50246361
Substrate
n/a
Meas. Tech.
ChEMBL_557990 (CHEMBL965585)
IC50
3±n/a nM
Citation
 Fan, J; Fahr, B; Stockett, D; Chan, E; Cheeti, S; Serafimova, I; Lu, Y; Pham, P; Walker, DH; Hoch, U; Choong, IC Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio. Bioorg Med Chem Lett 18:6236-9 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50246361
Synonyms:
CHEMBL455195 | N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)-2-ethylpiperidine-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C19H28N4O2S2
Mol. Mass.:
408.581
SMILES:
CCC1CC(CCN1)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1
Structure:
Search PDB for entries with ligand similarity: