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Target
Cyclin-dependent kinase 1
Ligand
BDBM50246357
Substrate
n/a
Meas. Tech.
ChEMBL_559443 (CHEMBL1018124)
IC50
71±n/a nM
Citation
 Jones, CD; Andrews, DM; Barker, AJ; Blades, K; Daunt, P; East, S; Geh, C; Graham, MA; Johnson, KM; Loddick, SA; McFarland, HM; McGregor, A; Moss, L; Rudge, DA; Simpson, PB; Swain, ML; Tam, KY; Tucker, JA; Walker, M The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing. Bioorg Med Chem Lett 18:6369-73 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Inhibitor
Name:
BDBM50246357
Synonyms:
(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone | CHEMBL455467
Type:
Small organic molecule
Emp. Form.:
C23H29N7O
Mol. Mass.:
419.5227
SMILES:
CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)C(=O)N2CCN(C)CC2)n1
Structure:
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